Cagrilintide CAS 1415456-99-3 is a long-acting amylinanalogue designed. As an agonist ofamylin receptors, it complementsincretin-based therapies by regulatingappetite, delaying gastric emptying,and promoting satiety. Clinical studieshave shown that cagrilintide,particularly in combination with GLP-1receptor agonists, may provideenhanced weight-loss efficacycompared with GLP-1 receptoragonist therapy alone.
Cagrilintide 1415456-99-3 is a long-acting amylinanalogue designed. As an agonist ofamylin receptors, it complementsincretin-based therapies by regulatingappetite, delaying gastric emptying,and promoting satiety. Clinical studieshave shown that cagrilintide,particularly in combination with GLP-1receptor agonists, may provideenhanced weight-loss efficacycompared with GLP-1 receptoragonist therapy alone.
| Chemical Name | Cagrilintide |
| CAS Number | 1415456-99-3 |
| Molecular Formula | C194H312N54O59S2 |
| Molecular Weight | 4409.01 |
| Molecular Structure |  |
| Packing | 10G/Bottle, 100G/Bottle, 500G/Bottle |
| Shelf-life | Two years |
| Storage Condition | Preserve in a tight, light-resistant containers at a temperature 2~8ºC |
| Application | Type 2 diabetes management Chronic weight management in eligible adults Cardiometabolic risk reduction in appropriate patient populations |
| Items | Specifications | |
| Solubility | Soluble in water | |
| MS (ESI) | 4409.10±1.0 | |
| Purity(HPLC) | ≥99.0% | |
| Related Substance(HPLC) | Total related substances≤1.0% | |
| Any individual impurity≤0.5% | ||
| Peptide Content | ≥85.0% | |
| Water Content (Karl Fischer) | ≤10.0% | |
| Amino Acid analysis | His 0.8-1.2 | |
| Asp 4.0-6.0 | ||
| Arg 1.6-2.4 | ||
| Lys 0.8-1.2 | ||
| Ile 0.8-1.2 | ||
| Leu 2.4-3.6 | ||
| Val 0.8-1.2 | ||
| Thr 4.0-6.0 | ||
| Phe 1.6-2.4 | ||
| Ser 2.4-3.6 | ||
| Ala 2.4-3.6 | ||
| Gly 1.6-2.4 | ||
| Glu 2.4-3.6 | ||
| Pro 3.2-4.8 | ||
| High molecular protein | ≤0.5% | |
| Acetate Content | ≤12.0% | |
| TFA Content | ≤0.25% | |
| Residual solvents | Acetonitrile NMT 410ppm | |
| Methanol NMT 3000ppm | ||
| Methylene chloride NMT 600ppm | ||
| N,N-Dimethylformamide NMT 880ppm | ||
| Isopropyl ether NMT 5000ppm | ||
| Bacterial endotoxins | <10EU/mg | |
| Microbial Limits | Total aerobic microbial count ≤1000cfu/g | |
| Total yeast and mold count ≤200cfu/g | ||
| Assay(HPLC) | 95.0~105.0%(on anhydrous and salt-free substance basis) |
* The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The users are suggested to select the suitability of the products and methods of application.
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