Promestriene CAS 39219-28-8 Synthetic Estrogen API

Human APIs

Promestriene

A synthetic estrogen used for local estrogen replacement in vaginal atrophy.

Model: CAS NO.: 39219-28-8

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Description

A topical estrogen agent with mild hormonal activity, acting locally on vaginal and vulvar mucosa to restore epithelial structure, relieve dryness and atrophy without significant systemic effects.

Chemical Name	PROMESTRIENE
CAS Number Molecular Formula Molecular Weight	39219-28-8 C22H32O2 328.49
Molecular Structure
Packing	25KG/Drum
Capacity	100KG/M
Storage	Stored at room temperature, tightly closed, in a dry cool place.
Application	Used topically for atrophic vaginitis, vulvar dystrophy, and vaginal dryness caused by estrogen deficiency in postmenopausal women. It exerts local estrogenic effects to restore vaginal mucosa and relieve related symptoms.

Specification

ITEMS		SPECIFICATION
Appearance		White crystalline powder, odorless.
Solubility		This product is freely soluble in acetone and ethyl acetate, sparingly soluble in methanol and ethanol, slightly soluble in dimethyl sulfoxide, and insoluble in water.
Identific ation	Physicochemical Identification	Should be positive reaction
	UV	There should be maximum absorption at wavelengths of 281nm and 287nm.
	IR	The infrared absorption spectrum of this product should be consistent with that of the reference substance
Melting point		64℃~68℃
Specific Rotation		+64° ~ +71°
Related substance		Total impurities ≤1.0%
Residual solvents		Methanol ≤0.3%
		Dimethyl sulfoxide ≤0.5%
		Ethanol ≤0.5%
Loss on drying		≤0.5%
Residue on ignition		≤0.1%
Heavy metal		≤10ppm
Assay		The assay of C22H32O2 should be 98.0% - 102.0%. (on dried basis). 98.0% - 102.0%. (on dried basis).

* The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The users are suggested to select the suitability of the products and methods of application.