ComWin supplies high purity Retatrutide API CAS 2381089-83-2, Retatrutide is a novel peptide therapeutic that functions as a triple agonist of the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors(GCG). The combined pharmacological actions of GLP-1, GIP, and glucagon receptor agonism may provide enhanced metabolic benefits compared with single- or dual-receptor agonists.
Retatrutide is a novel peptide therapeutic that functions as a triple agonist of the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors(GCG). The combined pharmacological actions of GLP-1, GIP, and glucagon receptor agonism may provide enhanced metabolic benefits compared with single- or dual-receptor agonists.
| Chemical Name | Retatrutide |
| CAS Number | 2381089-83-2 |
| Molecular Formula | C221H342N46O68 |
| Molecular Weight | 4731 |
| Molecular Structure |  |
| Packing | 10G/Bottle, 100G/Bottle, 500G/Bottle |
| Shelf-life | Two years |
| Storage Condition | Preserve in a tight, light-resistant containers at a temperature 2~8ºC |
| Application | Type 2 diabetes management Chronic weight management in eligible adults Cardiometabolic risk reduction in appropriate patient populations |
| Items | Specifications |
| Appearance | White or off-white powder |
| Solubility | ≥30mg/ml |
| MS (ESI) | 4731.33±1.0 |
| Purity(HPLC) | ≥98.0% |
| Related Substance (HPLC) | Any individual impurity≤1.0% |
| Peptide Content | ≥85.0% |
| Water Content (Karl Fischer) | ≤10.0% |
| PH(5.0MG/ML) | 6.0-8.0 |
| Amino Acid analysis | Asp, His, Tyr, Lys, Ile, Leu, Val, Arg, Thr, Phe, Ser, Ala, Gly, Glu |
| Acetate Content | ≤0.5% |
| TFA Content | ≤ 0.5% |
| Residual solvents | Isopropyl alcohol NMT 5000ppm Acetonitrile NMT 410ppm Methyl tert-butyl ether NMT 600ppm Methanol NMT 3000ppm N,N-Dimethylformamide NMT 880ppm |
| Bacterial endotoxins | <10EU/mg |
| Microbial Limits | Total aerobic microbial count ≤1000cfu/g Total yeast and mold count ≤200cfu/g |
| Assay(HPLC) | 95.0~105.0% (on anhydrous and salt-free substance basis) |
| Standard | In-House Standard |
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