Molecular Weight

958.22

Molecular Structure

Packing

25kg/drum

Capacity

Production upon order

Storage

Store in a tightly sealed container away from heat and direct light, and in a cool dry place.

Application

It is currently used as an immunosuppressant to prevent rejection of organ transplants and treatment of renal cell cancer and other tumours.

Appearance

 White to off-white powder

Identification
FT-IR
     HPLC Retention Time

Corresponds to standard
Corresponds to standard

Water(K.F)

NMT 3.0%

Residue on ignition

NMT 0.1%

Heavy Metals

NMT 10 ppm

Chromatographic Purity
Everolimus Isomer B
Everolimus Isomer C
Everolimus Isomer B+C

NLT 97.0%
NMT 3.0%
NLT 99.0%

Related Substance
Papamycin
Any Other Individual Impurity
Total Impurities

NMT 0.2%
NMT 0.10%
NMT 1.0%

Assay

98.0-102.0% (Antydrous and Solvent Free Basis)

Residual Solvents
Acetone
Acetonitrile
Methylene Chloride
Ethyl Acetate
Toluene
N-Hexane

NMT 5000 PPM
       NMT 410 PPM
       NMT 600 PPM
       NMT 5000 PPM
       NMT 890 PPM
       NMT 290 PPM

Standard

FS