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Sacubitril (LCZ696)
Contact us Product DetailsLCZ-696(SACUBITRIL+VALSARTAN)
| Chemical Name | LCZ-696(Sacubitril+Valsartan) | |
| CAS Number Molecular Formula Molecular Weight | 936623-90-4 2(C24H29N5O3).2(C24H29NO5).5(H2O).6Na 1922.06 | |
| Molecular Structure |  | |
| Packing | As customer’s requirements | |
| Storage | Store in a tightly sealed container away from heat and direct light, and in a cool dry place. | |
| Usage | ||
LCZ696 (sacubitril/Valsartan) is a combination drug for use in heart failure developed by Novartis. It consists of valsartan and sacubitril, in a 1:1 mixture by molecule count.
SPECIFICATION
| Items | Specification |
| Appearance | Off-white to white powder |
| Water | Between 4.0% to 5.9% |
| Isomers | XST-A: ≤0.5% |
| LCZ-Q: ≤0.1% | |
| LCZ-R: ≤0.1% | |
| LCZ-S: ≤0.1% | |
| Related Substances | LCZ-A≤1.2% |
| Any unknown impurity:≤0.10% | |
| Total impurities: ≤1.5% | |
| Residue Solvents | Ethanol: ≤0.5% |
| Ethyl ester: ≤0.5% | |
| Butanone≤0.5% | |
| Acetone≤0.5% | |
| Triethylamine: ≤0.032% | |
| N-hexane: ≤0.029% | |
| Assay | Valsartan 49.8%~52.4% |
| AHU377 47.1%~49.6% | |
| LCZ696 97.0%~102.0% |
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