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  • Product Name :

    Polysulfated Glycosaminoglycan

  • CAS No. :64082-61-7
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Product Details


Polysulfated-Glycosaminoglycan (PSGAG) is mostly used in dogs and horses for treating traumatic arthritis and degenerative joint disease (osteoarthritis). It has shown to be better at treating acute than chronic arthritis, though some studies say that its effectiveness in acute cases is still limited if degenerative enzymes haven't played a role. While it is currently only FDA-approved for dogs and horses, PSGAG is also used off-label to treat lameness in swine, as a chondroprotectant ("joint protector") or treatment of interstitial cystitis in cats, and to treat arthritis in rabbits.

                                         


Items
Specification

Characters

White to yellowish white powder

Identification

The retention time of the major peak of the sample preparation corresponds to that of standard preparation.

Sulfate/carboxylate Ratio: 2.5-4.0

Sodium: Positive

Toluidine Blue O Reaction: Positive

Specific Rotation

Between -8.0 and -15.0

Molecular Weight and Molecular Weight distribution

Mw:7300-9300

PDI:1.0-1.5

PH

5.5-8.0

Glucuronic Acid

18.0%-25.0%

Nucleotides

NMT0.2%

Nitrogen

1.5%-2.5%

Related substances

Chondroitin Sulfate by HPLC: NMT5.0%

Unspecified Impurity:

Individual: NMT0.20%

Total: NMT1.0%

Residual SolventEthanol

NMT 5000ppm

Acetic Acid

NMT 5000ppm

Free Sulfate

NMT 5.0%

Loss on Drying

NMT 5.0%

Residue on Ignition

38.0% - 48.0%

Heavy Metals

NMT 20ppm

Microbiological Examination

Total aerobic microbial count: NMT 103   cfu/g

Total combined yeasts/molds count:   NMT102 cfu/g

Bacterial Endotoxins

NMT2.5 EU/mg

Content

NLT 85.0% (on the dried basis)

Standard

In-house


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