MATERIAL SAFETY DATA SHEET 

VERSION:1.0/USP 

REVISION DATE: 26/06/2021

SECTION 1- PRODUCT IDENTIFICATION

PRODUCT NAME: ISOBUTYRONITRILE DATE OF ISSUE: 26 JUNE 2021 SUPPLIER: CHANGZHOU COMWIN FINE CHEMICALS CO., LTD. 

SECTION 2 -COMPOSITION/INFORMATION ON INGREDIENTS 

CAS NO.: 78-82-0

FORMULA: C4H7N 

SYNONYMS: 2-Methylpropionitrile 2-Methylpropanenitrile Isopropyl cyanide 

SECTION 3 - HAZARDS IDENTIFICATION 

APPEARANCE: CLEAR, COLORLESS LIQUID. FLASH POINT: 8 DEG C. DANGER! HIGHLY FLAMMABLE. MAY BE FATAL IF INHALED, ABSORBED THROUGH THE SKIN OR SWALLOWED. CAUSES EYE AND SKIN IRRITATION. CAUSES DIGESTIVE AND RESPIRATORY TRACT IRRITATION. METABOLIZED TO CYANIDE IN THE BODY, WHICH MAY CAUSE HEADACHE, DIZZINESS, WEAKNESS, UNCONSCIOUSNESS, CONVULSIONS, COMA AND POSSIBLE DEATH. TARGET ORGANS: NONE. POTENTIAL HEALTH EFFECTS EYE: CAUSES EYE IRRITATION. 

SKIN: CAUSES SKIN IRRITATION. MAY BE FATAL IF ABSORBED THROUGH THE SKIN. 

INGESTION: MAY BE FATAL IF SWALLOWED. CAUSES GASTROINTESTINAL IRRITATION WITH NAUSEA, VOMITING AND DIARRHEA. INGESTION MAY RESULT IN SYMPTOMS SIMILAR TO CYANIDE POISONING WHICH IS CHARACTERIZED BY ASPHYXIATION. 

INHALATION: CAUSES RESPIRATORY TRACT IRRITATION. VAPORS MAY CAUSE DIZZINESS OR SUFFOCATION. INHALATION MAY RESULT IN SYMPTOMS SIMILAR TO CYANIDE POISONING WHICH INCLUDE TACHYPNEA, HYPERPNEA (ABNORMALLY RAPID OR DEEP BREATHING), AND DYSPNEA (LABORED BREATHING) FOLLOWED RAPIDLY BY RESPIRATORY DEPRESSION. PULMONARY EDEMA MAY OCCUR. 

CHRONIC: MAY BE METABOLIZED TO CYANIDE WHICH IN TURN ACTS BY INHIBITING CYTOCHROME OXIDASE IMPAIRING CELLULAR RESPIRATION. 

SECTION 4 -FIRST AID MEASURES EYES: IMMEDIATELY FLUSH EYES WITH PLENTY OF WATER FOR AT LEAST 15 MINUTES, OCCASIONALLY LIFTING THE UPPER AND LOWER EYELIDS. GET MEDICAL AID IMME DIATELY.

SKIN: FLUSH SKIN WITH PLENTY OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED CLOTHING AND SHOES. WASH CLOTHING BEFORE REUSE. DESTROY CONTAMINATED SHOES. SPEEDY ACTION IS CRITICAL, GET MEDICAL AID IMMEDIATELY. 

INGESTION: CALL A POISON CONTROL CENTER. IF SWALLOWED, DO NOT INDUCE VOMITING UNLESS DIRECTED TO DO SO BY MEDICAL PERSONNEL. NEVER GIVE ANYTHING BY MOUTH TO AN UNCONSCIOUS PERSON. GET MEDICAL AID. 

INHALATION: GET MEDICAL AID IMMEDIATELY. REMOVE FROM EXPOSURE AND MOVE TO FRESH AIR IMMEDIATELY. IF NOT BREATHING, GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. DO NOT USE MOUTH-TO-MOUTH RESUSCITATION. NOTES TO PHYSICIAN: TREAT SYMPTOMATICALLY AND SUPPORTIVELY. 

SECTION 5 -FIRE FIGHTING MEASURES 

GENERAL INFORMATION: AS IN ANY FIRE, WEAR A SELF-CONTAINED BREATHING APPARATUS IN PRESSUREDEMAND, MSHA/NIOSH (APPROVED OR EQUIVALENT), AND FULL PROTECTIVE GEAR. VAPORS MAY FORM AN EXPLOSIVE MIXTURE WITH AIR. VAPORS CAN TRAVEL TO A SOURCE OF IGNITION AND FLASH BACK. DURING A FIRE, IRRITATING AND HIGHLY TOXIC GASES MAY BE GENERATED BY THERMAL DECOMPOSITION OR COMBUSTION. USE WATER SPRAY TO KEEP FIRE-EXPOSED CONTAINERS COOL. WATER MAY BE INEFFECTIVE. MATERIAL IS LIGHTER THAN WATER AND A FIRE MAY BE SPREAD BY THE USE OF WATER. FLAMMABLE LIQUID AND VAPOR. VAPORS MAY BE HEAVIER THAN AIR. THEY CAN SPREAD ALONG THE GROUND AND COLLECT IN LOW OR CONFINED AREAS. WILL BE EASILY IGNITED BY HEAT, SPARKS OR FLAME. CONTAINERS MAY EXPLODE IF EXPOSED TO FIRE. 

EXTINGUISHING MEDIA: FOR SMALL FIRES, USE DRY CHEMICAL, CARBON DIOXIDE, WATER SPRAY OR ALCOHOLRESISTANT FOAM. WATER MAY BE INEFFECTIVE. WATER MAY SPREAD FIRE. IF WATER IS THE ONLY MEDIA AVAILABLE, USE IN FLOODING AMOUNTS. FOR LARGE FIRES, USE WATER SPRAY, FOG OR ALCOHOL-RESISTANT FOAM. DO NOT USE STRAIGHT STREAMS OF WATER. COOL CONTAINERS WITH FLOODING QUANTITIES OF WATER UNTIL WELL AFTER FIRE IS OUT. 

FLASH POINT: 8 DEG C ( 46.40 DEG F) 

AUTOIGNITION TEMPERATURE: 482 DEG C ( 899.60 DEG F) 

EXPLOSION LIMITS, LOWER:NOT AVAILABLE. 

UPPER: NOT AVAILABLE.

NFPA RATING: (ESTIMATED) HEALTH: 3; FLAMMABILITY: 3; INSTABILITY: 0 

SECTION 6 -ACCIDENTAL RELEASE MEASURES 

GENERAL INFORMATION: USE PROPER PERSONAL PROTECTIVE EQUIPMENT AS INDICATED IN SECTION 8.

SPILLS/LEAKS: ABSORB SPILL WITH INERT MATERIAL (E.G. VERMICULITE, SAND OR EARTH), THEN PLACE IN SUITABLE CONTAINER. AVOID RUNOFF INTO STORM SEWERS AND DITCHES WHICH LEAD TO WATERWAYS. CLEAN UP SPILLS IMMEDIATELY, OBSERVING PRECAUTIONS IN THE PROTECTIVE EQUIPMENT SECTION. SCOOP UP WITH A NONSPARKING TOOL, THEN PLACE INTO A SUITABLE CONTAINER FOR DISPOSAL. REMOVE ALL SOURCES OF IGNITION. PROVIDE VENTILATION. 

SECTION 7 -HANDLING AND STORAGE 

HANDLING: GROUND AND BOND CONTAINERS WHEN TRANSFERRING MATERIAL. AVOID CONTACT WITH EYES, SKIN, AND CLOTHING. EMPTY CONTAINERS RETAIN PRODUCT RESIDUE, (LIQUID AND/OR VAPOR), AND CAN BE DANGEROUS. KEEP CONTAINER TIGHTLY CLOSED. KEEP AWAY FROM HEAT, SPARKS AND FLAME. AVOID INGESTION AND INHALATION. USE WITH ADEQUATE VENTILATION. WASH CLOTHING BEFORE REUSE. DO NOT PRESSURIZE, CUT, WELD, BRAZE, SOLDER, DRILL, GRIND, OR EXPOSE EMPTY CONTAINERS TO HEAT, SPARKS OR OPEN FLAMES. 

STORAGE: KEEP AWAY FROM HEAT, SPARKS, AND FLAME. KEEP AWAY FROM HEAT AND FLAME. STORE IN A TIGHTLY CLOSED CONTAINER. STORE IN A COOL, DRY, WELL-VENTILATED AREA AWAY FROM INCOMPATIBLE SUBSTANCES. FLAMMABLES-AREA. 

SECTION 8 -EXPOSURE CONTROLS/PPE PERSONAL PROTECTIVE EQUIPMENT 

RESPIRATORY PROTECTION WHERE RISK ASSESSMENT SHOWS AIR-PURIFYING RESPIRATORS ARE APPROPRIATE USE A FULL-FACE RESPIRATOR WITH MULTI-PURPOSE COMBINATION (US) OR TYPE ABEK (EN 14387) RESPIRATOR CARTRIDGES AS A BACKUP TO ENGINEERING CONTROLS. IF THE RESPIRATOR IS THE SOLE MEANS OF PROTECTION, USE A FULL-FACE SUPPLIED AIR RESPIRATOR. USE RESPIRATORS AND COMPONENTS TESTED AND APPROVED UNDER APPROPRIATE GOVERNMENT STANDARDS SUCH AS NIOSH (US) OR CEN (EU). 

HAND PROTECTION HANDLE WITH GLOVES. 

EYE PROTECTION FACE SHIELD AND SAFETY GLASSES 

SKIN AND BODY PROTECTION CHOOSE BODY PROTECTION ACCORDING TO THE AMOUNT AND CONCENTRATION OF THE DANGEROUS SUBSTANCE AT THE WORK PLACE. 

HYGIENE MEASURES AVOID CONTACT WITH SKIN, EYES AND CLOTHING. WASH HANDS BEFORE BREAKS AND IMMEDIATELYAFTER HANDLING THE PRODUCT

SECTION 9 -PHYSICAL AND CHEMICAL PROPERTIES 

APPEARANCE：COLORLESS TRANSPARENT LIQUID PURITY：≥97.0% WATER：≤0.5% 

SECTION 10 -STABILITY AND REACTIVITY 

CHEMICAL STABILITY: STABLE AT ROOM TEMPERATURE IN CLOSED CONTAINERS UNDER NORMAL STORAGE AND HANDLING CONDITIONS. 

CONDITIONS TO AVOID: INCOMPATIBLE MATERIALS, IGNITION SOURCES, EXCESS HEAT, STRONG OXIDANTS. 

INCOMPATIBILITIES WITH OTHER MATERIALS: STRONG ACIDS, STRONG BASES, STRONG OXIDIZING AGENTS. 

HAZARDOUS DECOMPOSITION PRODUCTS: NITROGEN OXIDES, CARBON MONOXIDE, IRRITATING AND TOXIC FUMES AND GASES, CARBON DIOXIDE, NITROGEN. 

HAZARDOUS POLYMERIZATION: HAS NOT BEEN REPORTED. 

SECTION 11 -TOXICOLOGICAL INFORMATION ACUTE TOXICITY LD50 ORAL - RAT - 50 MG/KG REMARKS: BEHAVIORAL:CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD. BEHAVIORAL:MUSCLE WEAKNESS. VASCULAR:REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION. INHALATION: NO DATAAVAILABLE LC50 INHALATION - RAT - MALE - 1 H - 5500 PPM 

SKIN CORROSION/IRRITATION NO DATAAVAILABLE SERIOUS EYE DAMAGE/EYE IRRITATION NO DATAAVAILABLE 

RESPIRATORY OR SKIN SENSITIZATION NO DATA AVAILABLE 

GERM CELL MUTAGENICITY NO DATAAVAILABLE 

CARCINOGENICITY 

IARC: NO COMPONENT OF THIS PRODUCT PRESENT AT LEVELS GREATER THAN OR EQUAL TO 0.1% IS IDENTIFIED AS PROBABLE, POSSIBLE OR CONFIRMED HUMAN CARCINOGEN BY IARC. 

ACGIH: NO COMPONENT OF THIS PRODUCT PRESENT AT LEVELS GREATER THAN OR EQUAL TO 0.1% IS IDENTIFIED AS A CARCINOGEN OR POTENTIAL CARCINOGEN BY ACGIH. 

NTP: NO COMPONENT OF THIS PRODUCT PRESENT AT LEVELS GREATER THAN OR EQUAL TO 0.1% IS IDENTIFIED AS A KNOWN OR ANTICIPATED CARCINOGEN BY NTP. 

OSHA: NO COMPONENT OF THIS PRODUCT PRESENT AT LEVELS GREATER THAN OR EQUAL TO 0.1% IS IDENTIFIED AS A CARCINOGEN OR POTENTIAL CARCINOGEN BY OSHA. 

REPRODUCTIVE TOXICITY NO DATAAVAILABLE

SPECIFIC TARGET ORGAN TOXICITY - SINGLE EXPOSURE (GHS) INHALATION - MAY CAUSE RESPIRATORY IRRITATION. 

SPECIFIC TARGET ORGAN TOXICITY - REPEATED EXPOSURE (GHS) NO DATAAVAILABLE ASPIRATION HAZARD NO DATAAVAILABLE 

POTENTIAL HEALTH EFFECTS INHALATION MAY BE HARMFUL IF INHALED. CAUSES RESPIRATORY TRACT IRRITATION. INGESTION MAY BE FATAL IF SWALLOWED. 

SKIN CAUSES SKIN IRRITATION. MAY BE FATAL IF ABSORBED THROUGH SKIN. 

EYES CAUSES EYE IRRITATION. SIGNS AND SYMPTOMS OF EXPOSURE 

SIGNS AND SYMPTOMS OF EXPOSURE MAY CAUSE CYANOSIS., ALWAYS HAVE ON HAND A CYANIDE FIRST-AID KIT, 

SECTION 12 -ECOLOGICAL INFORMATION TOXICITY: NO DATA AVAILABLE 

PERSISTENCE AND DEGRADABILITY: NO DATA AVAILABLE 

BIOACCUMULATIVE POTENTIAL: NO DATA AVAILABLE 

MOBILITY IN SOIL: NO DATA AVAILABLE 

PBT AND VPVB ASSESSMENT NO DATAAVAILABLE 

OTHER ADVERSE EFFECTS:NO DATA AVAILABLE 

SECTION 13 -DISPOSAL CONSIDERATIONS PRODUCT 

BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER BUT EXERT EXTRA CARE IN IGNITING AS THIS MATERIAL IS HIGHLY FLAMMABLE. OBSERVE ALL FEDERAL, STATE, AND LOCAL ENVIRONMENTAL REGULATIONS. CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF THIS MATERIAL. 

CONTAMINATED PACKAGING DISPOSE OF AS UNUSED PRODUCT. 

SECTION 14 -TRANSPORT INFORMATION 

DOT (US) UN-NUMBER: 2284 CLASS: 3 (6.1) PACKING GROUP: II PROPER SHIPPING NAME: ISOBUTYRONITRILE MARINE POLLUTANT: NO POISON INHALATION HAZARD: NO 

IMDG UN-NUMBER: 2284 CLASS: 3 (6.1) PACKING GROUP: II EMS-NO: F-E, S-D PROPER SHIPPING NAME: ISOBUTYRONITRILE MARINE POLLUTANT: NO 

IATA UN-NUMBER: 2284 CLASS: 3 (6.1) PACKING GROUP: II PROPER SHIPPING NAME: ISOBUTYRONITRILE

SECTION 15 -REGULATORY INFORMATION OSHA HAZARDS 

FLAMMABLE LIQUID, HIGHLY TOXIC BY INGESTION, HIGHLY TOXIC BY SKIN ABSORPTION, IRRITANT DSL STATUS ALL COMPONENTS OF THIS PRODUCT ARE ON THE CANADIAN DSL LIST. 

SARA 302 COMPONENTS SARA 313 COMPONENTS SARA 313: THIS MATERIAL DOES NOT CONTAIN ANY CHEMICAL COMPONENTS WITH KNOWN CAS NUMBERS THAT EXCEED THE THRESHOLD (DE MINIMIS) REPORTING LEVELS ESTABLISHED BY SARA TITLE III, SECTION 313. 

SARA 311/312 HAZARDS FIRE HAZARD, ACUTE HEALTH HAZARD 

MASSACHUSETTS RIGHT TO KNOW COMPONENTS ISOBUTYRONITRILE CAS-NO. 78-82-0 REVISION DATE 2007-07-01 

PENNSYLVANIA RIGHT TO KNOW COMPONENTS ISOBUTYRONITRILE CAS-NO. 78-82-0 REVISION DATE 2007-07-01 NEW JERSEY RIGHT TO KNOW COMPONENTS ISOBUTYRONITRILE CAS-NO. 78-82-0 REVISION DATE 2007-07-01 

ALIFORNIA PROP. 65 COMPONENTS THIS PRODUCT DOES NOT CONTAIN ANY CHEMICALS KNOWN TO STATE OF CALIFORNIA TO CAUSE CANCER, BIRTH DEFECTS, OR ANY OTHER REPRODUCTIVE HARM. SECTION 16 -OTHER INFORMATION 

THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. THE INFORMATION IN THIS DOCUMENT IS BASED ON THE PRESENT STATE OF OUR KNOWLEDGE AND IS APPLICABLE TO THE PRODUCT WITH REGARD TO APPROPRIATE SAFETY PRECAUTIONS. IT DOES NOT REPRESENT ANY GUARANTEE OF THE PROPERTIES OF THE PRODUCT.